SrasV1, Main, Exploration, bibRecord, 005E34

SARS: clinical virology and pathogenesis.

Identifieur interne : 005E34 ( Main/Exploration ); précédent : 005E33; suivant : 005E35

SARS: clinical virology and pathogenesis.

Auteurs : John Nicholls [République populaire de Chine] ; Xiao-Ping Dong ; Gu Jiang ; Malik Peiris

Source :

Respirology (Carlton, Vic.) [ 1323-7799 ] ; 2003.

RBID : pubmed:15018126

Descripteurs français

KwdFr :
- Humains, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Techniques histologiques, Virus du SRAS (isolement et purification), Virus du SRAS (pathogénicité).
MESH :
- anatomopathologie : Syndrome respiratoire aigu sévère.
- isolement et purification : Virus du SRAS.
- pathogénicité : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Humains, Techniques histologiques.

English descriptors

KwdEn :
- Histological Techniques, Humans, SARS Virus (isolation & purification), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology).
MESH :
- isolation & purification : SARS Virus.
- pathogenicity : SARS Virus.
- pathology : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Histological Techniques, Humans.

Abstract

Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus, called the SARS coronavirus (SARS-CoV). Over 95% of well characterized cohorts of SARS have evidence of recent SARS-CoV infection. The genome of SARS-CoV has been sequenced and it is not related to any of the previously known human or animal coronaviruses. It is probable that SARS-CoV was an animal virus that adapted to human-human transmission in the recent past. The virus can be found in nasopharyngeal aspirate, urine and stools of SARS patients. Second generation reverse transcriptase polymerase chain reaction assays are able to detect SARS-CoV in nasopharyngeal aspirates of approximately 80% of patients with SARS within the first 3 days of illness. Seroconversion for SARS-CoV using immunofluorescence on infected cells is an excellent method of confirming the diagnosis, but antibody responses only appear around day 10 of the illness. Within the first 10 days the histological picture is that of acute phase diffuse alveolar damage (DAD) with a mixture of inflammatory infiltrate, oedema and hyaline membrane formation. Desquamation of pneumocytes is prominent and consistent. After 10 days of illness the picture changes to one of organizing DAD with increased fibrosis, squamous metaplasia and multinucleated giant cells. The role of cytokines in the pathogenesis of SARS is still unclear.

DOI: 10.1046/j.1440-1843.2003.00517.x
PubMed: 15018126

Affiliations:

République populaire de Chine

Le document en format XML

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<term>Severe Acute Respiratory Syndrome (virology)</term>
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<term>Techniques histologiques</term>
<term>Virus du SRAS (isolement et purification)</term>
<term>Virus du SRAS (pathogénicité)</term>
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<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term>
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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus, called the SARS coronavirus (SARS-CoV). Over 95% of well characterized cohorts of SARS have evidence of recent SARS-CoV infection. The genome of SARS-CoV has been sequenced and it is not related to any of the previously known human or animal coronaviruses. It is probable that SARS-CoV was an animal virus that adapted to human-human transmission in the recent past. The virus can be found in nasopharyngeal aspirate, urine and stools of SARS patients. Second generation reverse transcriptase polymerase chain reaction assays are able to detect SARS-CoV in nasopharyngeal aspirates of approximately 80% of patients with SARS within the first 3 days of illness. Seroconversion for SARS-CoV using immunofluorescence on infected cells is an excellent method of confirming the diagnosis, but antibody responses only appear around day 10 of the illness. Within the first 10 days the histological picture is that of acute phase diffuse alveolar damage (DAD) with a mixture of inflammatory infiltrate, oedema and hyaline membrane formation. Desquamation of pneumocytes is prominent and consistent. After 10 days of illness the picture changes to one of organizing DAD with increased fibrosis, squamous metaplasia and multinucleated giant cells. The role of cytokines in the pathogenesis of SARS is still unclear.</div>
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<name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name>
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Serveur d'exploration SRAS

SARS: clinical virology and pathogenesis.

SARS: clinical virology and pathogenesis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration SRAS
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